The two victims were pronounced dead on the scene.
Early Wednesday evening, police identified them as 22-year-old Marcus Deering and 32-year-old Melvin Alston.
Calls came in about the incident at 3:08 a.m.
Police say this happened at a party in the 400 block of the Berkley Avenue Extension.
An argument started among the people attending the party and escalated to gunfire that led to the four victims being struck.
Police say a female who was shot had injuries that were not life-threatening and she was taken to Sentara Norfolk General.
A fourth gunshot victim was located later. He also had non-life threatening injuries and sought treatment in Portsmouth prior to police arrival.
Police are still searching for the suspect(s).
If anyone has information on this incident they are asked to call the Norfolk Crime Line 1-888-LOCK-U-UP.
Stay with NewsChannel 3 for more updates.