It happened at the intersection of Dolton Drive and Bonney Road. The bus was carrying kids from the SECEP program which is a special education and alternative education program.
The bus was coming from Renaissance Academy, according to a school official.
NewsChannel 3 has been told that the victim was a female student. She was transported to the hospital with serious injuries.
Officials say there was an argument on the bus that led to a person trying to exit the bus through the front door; when that didn't work, officials say the person went to the back door and went out.
Police are still on the scene investigating.
Check back on WTKR.com for updates as they become available.